Clinical Studies

ProAntro^® has been tested in four clinical studies to date: two on the efficacy of alcoholic liver detoxification, one on the efficacy of anti-fatigue, and one on safety.

These results have shown positive benefits of ProAntro^® on improving liver health after alcohol consumption, supporting the liver in rapidly metabolizing alcohol in the body, reducing daily fatigue, and confirming the safety of ProAntro^® for long-term consumption.

Human Efficacy and Safety Studies

Improve Liver Function after Alcohol Hepatitis

．Benefits of ProAntro^® on liver function after alcohol hepatitis

．Randomized, double-blinded, placebo-controlled

．Location: Korea

．80 heavy alcohol drinkers with serum γ-GT levels of 60–180 U/L

．Participants had either ProAntro^® (300 mg/day) or placebo for a period of 12 weeks

．Effect of ProAntro^® on blood ethanol and acetaldehyde levels, and the unpleasant symptoms after alcohol consumption

Randomized, double-blinded, placebo-controlled

．Location: Japan

．40 healthy participants

．Participants only had ProAntro^® (300 mg) once prior to alcohol consumption

．Influence of ProAntro^® on the fatigue experienced by individuals engaged in physical labor

Randomized, double-blinded, placebo-controlled

．Location: Japan

．64 healthy participants

．Participants had either ProAntro^® (300 mg/day) or placebo for a period of 12 weeks

．Safety after twice daily ProAntro^® administration for 90 days

．Open-label

．Location: Taiwan

．30 healthy participants

．Participants had 1,500 mg ProAntro^®, twice daily (a total of 3,000 mg daily) for 90 days

12-week consumption of 300 mg ProAntro^® on a daily basis, significantly decreases ALT level by 26.2 %, AST level by 20.7 %, and TG level by 16.8 % in the heavily alcohol-drinking population.

In conclusion, 300 mg/day of ProAntro^® consumed for 12 weeks helps to restore liver function after alcohol hepatitis.

Increase Alcohol Metabolism from the Body

ProAntro^®increases ethanol and acetaldehyde metabolism. _{(Chen et al., 2019)}

ProAntro^®significantly decreases blood ethanol and acetaldehyde levels after alcohol consumption as compared to the placebo.

ProAntro^®significantly reduces uncomfortable symptoms associated with alcohol consumption as compared to the placebo.

There was a significant decrease of 9.6 % in ethanol level and 13.4 % in acetaldehyde level in the ProAntro^® group compared to the placebo group within 60 minutes of alcohol consumption.

Blood acetaldehyde causes unconformable symptoms including fatigue, weakness, thirst, headache, muscle aches, nausea, stomach pain, vertigo, sensitivity to light and sound, anxiety, irritability, and increased blood pressure. _{(niaaa.nih.gov, 2021)}

In conclusion, ProAntro^® increases the metabolism of alcohol and acetaldehyde after alcohol consumption and helps to reduce uncomfortable symptoms associated with alcohol consumption.

Reduce Daily Fatigue, Increase Vigor-Activity

ProAntro^® has been shown to improve the “vigor-activity” score on the Profile of Mood States (POMS) and reduce everyday feelings of fatigue. _{(Chen et al., 2019)}

“Vigor-activity” score was significantly higher for those who ingested the ProAntro^® as compared to the placebo.

γ-GT and urea nitrogen levels, markers of liver and kidney function respectively, showed significant decreases for those who ingested the ProAntro^® as compared to the placebo.

The study shows that ProAntro^® has a positive effect on liver and kidney functions which plays an important role in our daily well-being.

In conclusion, ProAntro^® consumed on a daily basis has demonstrated a reduction in daily fatigue and an increase in daily “vigor-activity” score for physical laborers.

Long-Term Safety Consumption Study

A ninety (90)-day long-term study of ProAntro^® at 3,000 mg per day shows a high level of safety with no adverse events recorded._{(ClinicalTrials.gov. ID: NCT01007656)}

In the multiple-dose research study on the safety evaluation of ProAntro^®, participants consumed three 500 mg ProAntro^® capsules per dose, two times per day, every 12 hours for 90 days.

AST, ALT, albumin, glucose, creatinine, uric acid, cholesterol, TG, γ-GT, alkaline phosphatase, vital signs (heart rate, blood pressure, and body temperature), etc., were documented at 1st, 10th, 20th, 30th, 45th, 60th, and 90th day.

During the 90-day study, the 30 study subjects did not demonstrate any clinically significant issues in the safety parameters.

In conclusion, ProAntro® is safe to consume both on a daily and long-term basis.

Golden Biotechnology Japan

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Disclaimer: All statements mentioned on this website are for informative purposes only, not intended for diagnosis, cure, treatment or prevention of any disease, nor as medical advice or advertisement. The contents on this website are only intended to inform about the nutritional and physiological processes of the food supplement. The information provided on this site is not intended as a substitute for advice from your physician or other health care professionals.

Clinical Studies

ProAntro® has been tested in four clinical studies to date: two on the efficacy of alcoholic liver detoxification, one on the efficacy of anti-fatigue, and one on safety.

These results have shown positive benefits of ProAntro® on improving liver health after alcohol consumption, supporting the liver in rapidly metabolizing alcohol in the body, reducing daily fatigue, and confirming the safety of ProAntro® for long-term consumption.

Human Efficacy and Safety Studies

Improve Liver Function after Alcohol Hepatitis

．Benefits of ProAntro® on liver function after alcohol hepatitis

．Randomized, double-blinded, placebo-controlled

．Location: Korea

．80 heavy alcohol drinkers with serum γ-GT levels of 60–180 U/L

．Participants had either ProAntro® (300 mg/day) or placebo for a period of 12 weeks

Increase Metabolism of Alcohol from the Body

．Effect of ProAntro® on blood ethanol and acetaldehyde levels, and the unpleasant symptoms after alcohol consumption

Randomized, double-blinded, placebo-controlled

．Location: Japan

．40 healthy participants

．Participants only had ProAntro® (300 mg) once prior to alcohol consumption

Reduce Daily Fatigue, Increase Vigor-Activity

．Influence of ProAntro® on the fatigue experienced by individuals engaged in physical labor

Randomized, double-blinded, placebo-controlled

．Location: Japan

．64 healthy participants

．Participants had either ProAntro® (300 mg/day) or placebo for a period of 12 weeks

Long-Term Safety Consumption Study

．Safety after twice daily ProAntro® administration for 90 days

．Open-label

．Location: Taiwan

．30 healthy participants

．Participants had 1,500 mg ProAntro®, twice daily (a total of 3,000 mg daily) for 90 days

Improve Liver Function after Alcohol Hepatitis

12-week consumption of 300 mg ProAntro® on a daily basis, significantly decreases ALT level by 26.2 %, AST level by 20.7 %, and TG level by 16.8 % in the heavily alcohol-drinking population.

In conclusion, 300 mg/day of ProAntro® consumed for 12 weeks helps to restore liver function after alcohol hepatitis.

Increase Alcohol Metabolism from the Body

ProAntro® increases ethanol and acetaldehyde metabolism. (Chen et al., 2019)

ProAntro® significantly decreases blood ethanol and acetaldehyde levels after alcohol consumption as compared to the placebo.

ProAntro® significantly reduces uncomfortable symptoms associated with alcohol consumption as compared to the placebo.

There was a significant decrease of 9.6 % in ethanol level and 13.4 % in acetaldehyde level in the ProAntro® group compared to the placebo group within 60 minutes of alcohol consumption.

Blood acetaldehyde causes unconformable symptoms including fatigue, weakness, thirst, headache, muscle aches, nausea, stomach pain, vertigo, sensitivity to light and sound, anxiety, irritability, and increased blood pressure. (niaaa.nih.gov, 2021)

In conclusion, ProAntro® increases the metabolism of alcohol and acetaldehyde after alcohol consumption and helps to reduce uncomfortable symptoms associated with alcohol consumption.

Reduce Daily Fatigue, Increase Vigor-Activity

ProAntro® has been shown to improve the “vigor-activity” score on the Profile of Mood States (POMS) and reduce everyday feelings of fatigue. (Chen et al., 2019)

“Vigor-activity” score was significantly higher for those who ingested the ProAntro® as compared to the placebo.

γ-GT and urea nitrogen levels, markers of liver and kidney function respectively, showed significant decreases for those who ingested the ProAntro® as compared to the placebo.

The study shows that ProAntro® has a positive effect on liver and kidney functions which plays an important role in our daily well-being.

In conclusion, ProAntro® consumed on a daily basis has demonstrated a reduction in daily fatigue and an increase in daily “vigor-activity” score for physical laborers.

Long-Term Safety Consumption Study

A ninety (90)-day long-term study of ProAntro® at 3,000 mg per day shows a high level of safety with no adverse events recorded. (ClinicalTrials.gov. ID: NCT01007656)

In the multiple-dose research study on the safety evaluation of ProAntro®, participants consumed three 500 mg ProAntro® capsules per dose, two times per day, every 12 hours for 90 days.

AST, ALT, albumin, glucose, creatinine, uric acid, cholesterol, TG, γ-GT, alkaline phosphatase, vital signs (heart rate, blood pressure, and body temperature), etc., were documented at 1st, 10th, 20th, 30th, 45th, 60th, and 90th day.

During the 90-day study, the 30 study subjects did not demonstrate any clinically significant issues in the safety parameters.

In conclusion, ProAntro® is safe to consume both on a daily and long-term basis.

ProAntro^® has been tested in four clinical studies to date: two on the efficacy of alcoholic liver detoxification, one on the efficacy of anti-fatigue, and one on safety.

These results have shown positive benefits of ProAntro^® on improving liver health after alcohol consumption, supporting the liver in rapidly metabolizing alcohol in the body, reducing daily fatigue, and confirming the safety of ProAntro^® for long-term consumption.

．Benefits of ProAntro^® on liver function after alcohol hepatitis

．Participants had either ProAntro^® (300 mg/day) or placebo for a period of 12 weeks

．Effect of ProAntro^® on blood ethanol and acetaldehyde levels, and the unpleasant symptoms after alcohol consumption

．Participants only had ProAntro^® (300 mg) once prior to alcohol consumption

．Influence of ProAntro^® on the fatigue experienced by individuals engaged in physical labor

．Participants had either ProAntro^® (300 mg/day) or placebo for a period of 12 weeks

．Safety after twice daily ProAntro^® administration for 90 days

．Participants had 1,500 mg ProAntro^®, twice daily (a total of 3,000 mg daily) for 90 days

12-week consumption of 300 mg ProAntro^® on a daily basis, significantly decreases ALT level by 26.2 %, AST level by 20.7 %, and TG level by 16.8 % in the heavily alcohol-drinking population.

In conclusion, 300 mg/day of ProAntro^® consumed for 12 weeks helps to restore liver function after alcohol hepatitis.

ProAntro^®increases ethanol and acetaldehyde metabolism. _{(Chen et al., 2019)}

ProAntro^®significantly decreases blood ethanol and acetaldehyde levels after alcohol consumption as compared to the placebo.

ProAntro^®significantly reduces uncomfortable symptoms associated with alcohol consumption as compared to the placebo.

There was a significant decrease of 9.6 % in ethanol level and 13.4 % in acetaldehyde level in the ProAntro^® group compared to the placebo group within 60 minutes of alcohol consumption.

Blood acetaldehyde causes unconformable symptoms including fatigue, weakness, thirst, headache, muscle aches, nausea, stomach pain, vertigo, sensitivity to light and sound, anxiety, irritability, and increased blood pressure. _{(niaaa.nih.gov, 2021)}

In conclusion, ProAntro^® increases the metabolism of alcohol and acetaldehyde after alcohol consumption and helps to reduce uncomfortable symptoms associated with alcohol consumption.

ProAntro^® has been shown to improve the “vigor-activity” score on the Profile of Mood States (POMS) and reduce everyday feelings of fatigue. _{(Chen et al., 2019)}

“Vigor-activity” score was significantly higher for those who ingested the ProAntro^® as compared to the placebo.

γ-GT and urea nitrogen levels, markers of liver and kidney function respectively, showed significant decreases for those who ingested the ProAntro^® as compared to the placebo.

The study shows that ProAntro^® has a positive effect on liver and kidney functions which plays an important role in our daily well-being.

In conclusion, ProAntro^® consumed on a daily basis has demonstrated a reduction in daily fatigue and an increase in daily “vigor-activity” score for physical laborers.

A ninety (90)-day long-term study of ProAntro^® at 3,000 mg per day shows a high level of safety with no adverse events recorded._{(ClinicalTrials.gov. ID: NCT01007656)}

In the multiple-dose research study on the safety evaluation of ProAntro^®, participants consumed three 500 mg ProAntro^® capsules per dose, two times per day, every 12 hours for 90 days.